The AnteAGE MD® System Sample Pack contains two 0.89 ml products. This is approximately one application.

Specially designed to rejuvenate the skin and address several skin concerns including Rosacea.

This dual system, Serum and Accelerator, is provided in 0.89 ml packet. The full-size 30ml duo can be purchased from here

AnteAGE MD® Serum restores skin’s ability to heal itself. This aqueous formula quickly absorbs into your skin with a high concentration of physiologically balanced Stem Cytokines™ (derived from human bone marrow stem cells) fortified with two recombinant Growth Factors, TGF-β3 and IGF-1. The addition of classical actives such as peptides and antioxidants yield a robust and rational skincare system. Wrapped in nano-lipid carriers for enhanced penetration, these ingredients create exceptional results at the cellular level.

AnteAGE® MD System contains twice the Stem Cytokines found in AnteAGE, along with 21 additional ingredients with proven anti-ageing, pro-healing and anti-inflammatory benefits.

With daily use, it improves the health and appearance of skin at any age.

The stem cell technology behind AnteAGE® MD is cutting edge and published in multiple peer-reviewed medical journals.

AnteAGE® is suitable for all skin problems and types.

Serum

Growth Factors & Cytokines
Niacinamide
Carnosine
Palmitoyl Oligopeptide & Palmitoyl Tetrapeptide-7
Catechins & Flavonoids

Accelerator

Ceramides & Phospholipids
Growth Factors & Cytokines
Bakuchiol (derived from bakuchiol seed) has been compared to Retinol (a Vitamin A derivative) for improving wrinkles and ageing skin.
Human Beta-Defensin 3
Iris Isoflavones
Tetrahexyldecyl Ascorbate (Vitamin C)
Tocopheryl Acetate (Vitamin E)
Panthenol (Vitamin B5)
Coenzyme Q10
Grape Seed Extract

The Science

The AnteAGE® Skincare System was in development for 3+ years and launched in 2012 by The Cellese Corporation, the research laboratory and manufacturing is done in California, USA.

The key difference between growth factors (GF's) made by other brands is that the growth factors are harvested from bone marrow-derived mesenchymal stem cells (MSC's) a cytokine, "powerhouses" and not fibroblasts (fetal foreskin derived) or fat cells (adipocytes) extracted through liposuction.

MSC stem cells produce fifty times the concentration of key GF’s compared to fibroblasts.

Within the body, MSCs deplete as you get older. In fact, at age fifteen, one out of every 10,000 of the cells in your bone marrow are MSCs. At age fifty, only 2.5% of these cells remain.

This makes sense when you realise the different roles these cell types play in wound healing and regeneration. Fibroblasts are really the corporals in that war, taking orders from the generals – the stem cells. Stem cells bark the orders, fibroblasts listen and do the grunt work.

Extracted from an article written by founder Dr. George Taylor;

"MSC’s are grown in “farms” of millions of MSC’s under strict sterile conditions in a university laboratory. Their environment is highly controlled. We mimic the niche they live in with the body. We “talk” to them. They produce abundant cytokines in regenerative patterns. We isolate them, leaving all that cell stuff behind. Cytokines are further processed to package them for delivery through the skin (nanoliposomes)." www.barefacedtruth.com

"The human stem cell-derived growth factors are completely natural to humans. Organic if you will, in that they are a perfect molecular match to the same growth factors our own bodies make. That means that allergic reactions to these molecules are pretty much nonexistent." Extracted from blog article www.barefacedtruth.com

Serum

The first step in the AnteAGE® Skin Care System is a water-soluble blend of actives in a Serum. That flood the skin with the most anti-inflammatory and regenerative ingredients to prime it's the ability to repair, regenerate, and produce quality, Type One collagen. The characteristics of this tissue, create beautifully

Accelerator

The second step in the AnteAGE® Skin Care System is the Accelerator– a lipid-soluble form of active ingredients that acts as a compliment and a synergistic topical to our serum. The Accelerator helps to provide a well-rounded approach to skin health and it contains a high dose of lipid-soluble antioxidants housed in a base of ceramides and phospholipids.

If you wrap your molecules in a lipid envelope it can sneak into the spaces between cells which is lipid-soluble because it helps to make the substance electrically neutral.

They form a two-layer structure, called the lipid bilayer, with the polar head facing out on each surface to interact with water, and with the neutral “tails” driven inward and pointing toward one another. The lipid bilayer is the structural basis of all cell membranes and is nearly impermeable to ions and most polar molecules. Proteins embedded in the phospholipid matrix transport many substances through the membrane.

Definition of terms:

1. Bio-signals refers to cytokines & growth factors produced through laboratory culture of human cells.

2. Conditioned media is the name given to the nutrient culture broth after all cells have been filtered out and discarded. It contains the biosignals produced by the cells during culture.

3. Lysed cells are cells that have been ruptured or burst using repeated freeze-thaw cycles.

4. Exosomes are a type of extracellular vesicle that contain constituents (protein, DNA, and RNA) of the cells that secrete them. They are taken up by distant cells, where they can affect cell function and behaviour.

Origins

The research was conducted by Founders, Dr. John Sanderson and Dr. George Taylor. They are also the authors of an educational website called barefacedtruth.com that gives a very detailed explanation of the scientific discover around GF and is also a platform for debating their use in skincare.

AnteAGE® by Cellese Recent research revealed the important role bone marrow stem cells play in tissue repair and healing throughout the body, particularly in the skin.

The founders choose to employ not fibroblasts, but stem cells, and indeed a particular class of stem cell that is the subject of intensive work in many other stem cell laboratories around the world.

Like red cells, white cells, and platelets, which also originate in the bone marrow, these stem cells enter the bloodstream where they are carried to all tissues. Upon arrival at injuries, some may differentiate into cell types needed for repair (e.g. muscle, cartilage, nerve, etc.). Their major role, however, is to act as command and control of other nearby cells involved in healing. The pattern of bio-signals in conditioned media derived from the culture of bone marrow stem cells is strongly anti-inflammatory. On the basis of healing physiology, and the known deleterious effects of inflammation on the skin, bone marrow-derived mesenchymal stem cells appear to be the preferred cell to culture to obtain bio-signals for use in products to be applied to the skin. Clinical evidence supports this conclusion. Bone marrow stem cells are typically obtained from young adults in their early 20’s.

Claims: AnteAGE was effective in improving twelve parameters of skin health and appearance in 45 women and 4 men aged 30 to 75. These twelve parameters were: Tone, Dryness, Brightness, Softeners, Pore Size, Blotchiness, Redness, Age Spots, Fine Lines, Texture, Colour Blend, Deep Lines.

Clinical Results: 85% saw improvement in 6 or more criteria; 61% saw improvement in 9 or more criteria; 32% saw improvement in all 12 criteria. There were forty-eight participants and the study lasted five-weeks.

Application

MORNING & EVENING

1. Cleanse the skin, at night do a double cleanse to remove mineral SPF

2. No. 1 Serum Dispense 1-2 pump and apply to clean skin, both morning and evening. Start the application on the forehead and spread down the face using fingertips. Tap any residue around the eye bone and lip. Suitable to use on the neck form the onset. Allow to dry for a few seconds or fan the face.

3. No. 2 Serum - repeat instructions above.

4. During the day use a mineral SPF.

Ingredients

Serum No. 1 Ingredients:

Water (Aqua), Human Bone Marrow Stem Cell Conditioned Media, Hydrolyzed Myrtus Communis Leaf Extract, Glycerin, Butylene Glycol, Carbomer, Polysorbate 20, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Niacinamide, Cetyl Ethylhexanoate, Polyacrylate-13, Polyisobutene, Dimethyl Isosorbide, Benzyl Alcohol, Salicylic Acid, Sorbic Acid, Carnosine, Ilex Paraguariensis Leaf Extract, Maltodextrin, Disodium EDTA, TGF-beta 3 (sh-Polypeptide- 5), IGF-1 (sh-Oligopeptide-2)

Accelerator No. 2 Ingredients:
Water (Aqua), Butylene Glycol, Glycerin, C12-15 Alkyl Benzoate, Capric/Caprylic Triglyceride, Cetearyl Alcohol, Human Bone Marrow Stem Cell Conditioned Media, hBD3 (sh-Oligopeptide- 33), Tetrahexyldecyl Ascorbate, Bakuchiol, Tocopheryl Acetate, Iris Florentina Root Extract, Pentylene Glycol, Tamarindus Indica Seed Gum, Sodium Hyaluronate, Candelilla/Jojoba/Rice Bran Polyglyceryl-3 Esters, Glyceryl Stearate, Sodium Stearoyl Lactylate, Tremella Fuciformis Sporocarp Extract, Betaine, Potassium Sorbate, Glycosphingolipids, Tasmannia Lanceolata Fruit Extract, Syzygium Luehmannii Fruit Extract, Kunzea Pomifera Fruit Extract, Magnesium Aluminum Silicate, Limanthes Alba (Meadowfoam) Seed Oil, Simmondsia Chinensis (Jojoba) Seed Oil, Thioctic Acid, Ubiquinone, Xanthan Gum, Ethyl Linoleate, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol

FAQ

The stem cells are sourced only from the bone marrow of young, healthy, pre-screened adult donors. Stem cell cytokines also contain none of the original cell parts themselves, only the beneficial growth factors they produce.

The healing chemical signals produced by the mesenchymal stem cells (growth factors and cytokines) are harvested. The products are 100% free of inflammatory cells, cell fragments, RNA, or DNA.

The Serum contains only the harvested growth factors and cytokines.

The formulation is very stable and does not require refrigeration
The point after opening is recommended at twelve months
The expiration is two years