AnteAGE® Skincare is clinically proven to reverse ageing and restore healthy skin. The unique technology harnesses the healing bio-signals that are omitted naturally on a cellular level. These Growth Factors and Cytokines form part of the complex language, that responds to healing from injury and are shown to rejuvenate damaged skin.

The at-home facial kit addresses several different skin problems (Pigmentation and LInes) and is safe to use if you have either Hypersensitive Skin or Rosacea. Products containing conditioned media from bone marrow stem cell cultures. These have demonstrated a far more potent and consistent anti-inflammatory effect.

Crucially the combination treatment increases the production of firming collagen and elastin. The microchannel stamp improves penetration by four times more.

All the serums quickly absorb into your skin with a high concentration of physiologically balanced Stem Cytokines™ (derived from human bone marrow stem cells) fortified with two recombinant Growth Factors, TGF-β3 and IGF-1. A nanoliposomes delivery system ensures proper penetration.

Each kit has been designed for two complete facials. Apply to the face and neck.

Repeat the treatment every seven days.

What's Included:

Cleanser 5ml
Regenzyme Mask 10 ml
Home Growth Factor Solution 5 ml vial
Serum 5 ml (No. 1)
Accelerator 5 ml (No. 2)
Micro-channeling 0.25mm Stamp (re-usable)
Mini Brush Applicator (for enzyme mask)
Disposable Towel
Instructions Leaflet

*Click on the instructions tab.

With daily use, the AnteAGE® Skincare improves the health and appearance of skin at any age.

Before and After following a 5-week clinical study using The AnteAGE® Skincare System

AnteAGE® System contains Stem Cytokines, along with eighteen additional ingredients with proven anti-ageing, pro-healing and anti-inflammatory benefits. Each with peer-reviewed and published scientific proof of value in producing healthier younger-looking skin.

The corrective properties achieved from using AnteAge are very unique. It benefits every aspect of the skin, from how it functions on a cellular level to its appearance.

A more potent form of the Serum and Accelerator AnteAGE® MD is available to purchase by mail order here

How do I order this?

AnteAGE® MD is given on a named basis, under the supervision of a certified professional. It’s only available to purchase in a clinic or by mail order. To get started, please get in touch with order@medicobeauty.com with details of the items you would like to purchase and whether this is a new or repeat order.

The Science

The AnteAGE® Skincare System was in development for 3+ years and launched in 2012 by The Cellese Corporation, the research laboratory and manufacturing is done in California, USA.

The key difference between growth factors (GF's) made by other brands is that the growth factors are harvested from bone marrow-derived mesenchymal stem cells (MSC's) a cytokine, "powerhouses" and not fibroblasts (fetal foreskin derived) or fat cells (adipocytes) extracted through liposuction.

MSC stem cells produce fifty times the concentration of key GF’s compared to fibroblasts.

Within the body, MSCs deplete as you get older. In fact, at age fifteen, one out of every 10,000 of the cells in your bone marrow are MSCs. At age fifty, only 2.5% of these cells remain.

Extracted from an article written by founder Dr. George Taylor;

"This makes sense when you realise the different roles these cell types play in wound healing and regeneration. Fibroblasts are really the corporals in that war, taking orders from the generals – the stem cells. Stem cells bark the orders, fibroblasts listen and do the grunt work.

"MSC’s are grown in “farms” of millions of MSC’s under strict sterile conditions in a university laboratory. Their environment is highly controlled. We mimic the niche they live in with the body. We “talk” to them. They produce abundant cytokines in regenerative patterns. We isolate them, leaving all that cell stuff behind. Cytokines are further processed to package them for delivery through the skin (nanoliposomes)." www.barefacedtruth.com

"The human stem cell-derived growth factors are completely natural to humans. Organic if you will, in that they are a perfect molecular match to the same growth factors our own bodies make. That means that allergic reactions to these molecules are pretty much nonexistent." Extracted from blog article www.barefacedtruth.com

Definition of terms:

1. Bio-signals refers to cytokines & growth factors produced through laboratory culture of human cells.

2. Conditioned media is the name given to the nutrient culture broth after all cells have been filtered out and discarded. It contains the biosignals produced by the cells during culture.

3. Lysed cells are cells that have been ruptured or burst using repeated freeze-thaw cycles.

4. Exosomes are a type of extracellular vesicle that contain constituents (protein, DNA, and RNA) of the cells that secrete them. They are taken up by distant cells, where they can affect cell function and behaviour.

Origins

The research was conducted by Scientific Founders, Dr. John Sanderson and Dr. George Taylor. They are also the authors of an educational website called barefacedtruth.com that gives a very detailed explanation of the scientific discover around GF and is also a platform for debating their use in skincare.

AnteAGE® by Cellese Recent research revealed the important role bone marrow stem cells play in tissue repair and healing throughout the body, particularly in the skin.

The founders choose to employ not fibroblasts, but stem cells, and indeed a particular class of stem cell that is the subject of intensive work in many other stem cell laboratories around the world.

Like red cells, white cells, and platelets, which also originate in the bone marrow, these stem cells enter the bloodstream where they are carried to all tissues. Upon arrival at injuries, some may differentiate into cell types needed for repair (e.g. muscle, cartilage, nerve, etc.). Their major role, however, is to act as command and control of other nearby cells involved in healing. The pattern of bio-signals in conditioned media derived from the culture of bone marrow stem cells is strongly anti-inflammatory. On the basis of healing physiology, and the known deleterious effects of inflammation on the skin, bone marrow-derived mesenchymal stem cells appear to be the preferred cell to culture to obtain bio-signals for use in products to be applied to the skin. Clinical evidence supports this conclusion. Bone marrow stem cells are typically obtained from young adults in their early 20’s.

Claims: AnteAGE was effective in improving twelve parameters of skin health and appearance in 45 women and 4 men aged 30 to 75. These twelve parameters were: Tone, Dryness, Brightness, Softeners, Pore Size, Blotchiness, Redness, Age Spots, Fine Lines, Texture, Colour Blend, Deep Lines.

Clinical Results: 85% saw improvement in 6 or more criteria; 61% saw improvement in 9 or more criteria; 32% saw improvement in all 12 criteria. There were forty-eight participants and the study lasted five-weeks.

Instructions

Step One: Do a double-cleanse using the Cleanser. Used two pumps of Cleanse mixed with water, massage on the face and neck for a few seconds. Remove with water. Repeat the cleanse. Thoroughly dry the skin with a towel.

Step Two: Regenzyme Mask - start the application on the forehead using the small brush. Apply a medium layer down the face and neck.

It's normal for the skin to tingle for the first three minutes. Fan the mask to dry for one minute. If you wish to activate the enzyme in the mask, use steam.

Put the disposable towel (in the plastic wrapping) into the microwave for 15seconds. Remove the towel from the packet, shake to cool slightly and put over the face. Leave the mask to dry for ten minutes.

Remove the mask with the towel. Put some cool water onto the skin and use a damp cotton pad to remove any mask residue.

Step Three: Home Growth Factor Solution (5 ml vial) - apply the solution with the rollerball all over the face and neck. Start the application on the forehead and work down. The solution is safe to use on the eyelids and lips. If you find that not much serum is being dispensed, open the vial and use 1/4 of the serum. Apply with your fingertips. Fan to dry the face.

Step Four: Micro-channel Stamp (0.25 ml) - Divide the face into four sections. Leave the neck to last. Start on the forehead in the middle of the face. Press the stamp against the skin and work down the face in one line, moving from the centre to the hairline. Do the right side, then left side. After finishing the forehead, move into the lower part of the face, stamp the right, then left cheeks. It's safe to use the stamp around the eye bone (lower) and also an upper lid, just under the eyebrows. Don't forget to also stamp the lips then nose. Finally, stamp the neck.

After stamping the face and neck vertically, switch and repeat the same steps but stamp horizontally, working from the centre of the face outward.

This technique ensures the highest number of channels is created. The active ingredients are absorbed into the skin through the channels.

Step Five: Repeat the application of the Solution to the face and neck. Fan to dry for a few seconds.

Step Six: Dispense 2 pumps of the Serum (No. 1), star the application on the forehead and spread down the face and neck using fingertips. Tap any residue around the eye bone. Fan to dry for a few seconds.

Step Seven: Dispense 2 pumps of the Accelerator (No. 2), star the application on the forehead and spread down the face and neck using fingertips. Tap any residue around the eye bone. Fan to dry for a few seconds.

Dispense 1-2 pump and apply to clean skin, both morning and evening. Start the application on the forehead and spread down the face using fingertips. Tap any residue around the eye bone and lip. Suitable to use on the neck form the onset.

Avoid sauna and heat (exercise) for a minimum of two days. You may find the face is sore to touch and flushes more easily. Do not go into direct sunlight. Always wear a mineral sunscreen (made with Titanium or Zinc Oxide) and make-up.

If going outdoors, wait twenty minutes before applying a mineral sunscreen (SPF) or make-up twenty minutes after the treatment. This gives enough time for the small channels to close and no longer absorb any ingredients.

Use CoMedix Protect SPF30 (spray mineral sunscreen) and INIKA mineral makeup foundation. A trial pack is available to purchase on the website for £8.50

It's safe to wear mineral makeup immediately after the treatment. Liquid foundations can interfere with the active ingredients in the treatment and should be avoided.

POST TREATMENT

It's normal to see red and flushed skin. The skin may also flush the following morning after cleansing. For the next seven days, after cleansing use the Serum (No. 1) and Accelerator (No. 2) in the evening. The products can be used morning and evening but are likely to run out very quickly.

Use a gentle cleanser in the morning and evening.
For the next seven days, avoid using any Toners, exfoliating scrubs and masks.
You can return to using Antioxidant serums (products made with Vitamin C) in the following morning.
Ideally don't use a Retinol serum on the same night as the AnteAGE® Serum No. 1
You can alternate between Retinol serum and AnteAGE® No. Wait two nights before returning to use regular creams (made with AHAs) and Retinol.

Repeat the treatment every seven days.

CLEAN ROLLER - after using put roller into an alcohol solution for a few seconds, dry and reseal with the lid.

Ingredients

Cleanser:

Water (Aqua), Sodium Laurylglucosides Hydroxypropylsulfonate, Polyglyceryl-4 Caprylate, Sodium Chloride, Glycerin, Sodium Cocoyl Hydrolyzed Amaranth Protein, Gluconolactone, Sodium Cocoamphoacetate, Nymphaea Caerulea (Blue Lotus) Flower Extract, Ethyl Linoleate, Salix Nigra (Willow) Bark Extract, Camellia Oleifera (Green Tea) Leaf Extract, Zeolite, Sodium Hydroxypropylsulfonate Decylglucoside Crosspolymer, Lauryl Glucoside, Sodium Lauryl Glucose Carboxylate, Sodium Cocoyl Glutamate, Sodium Benzoate, Potassium Sorbate, Fragrance/Parfum

Serum No. 1 Ingredients:

Water (Aqua), Human Bone Marrow Stem Cell Conditioned Media, Hydrolyzed Myrtus Communis Leaf Extract, Glycerin, Butylene Glycol, Carbomer, Polysorbate 20, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Niacinamide, Cetyl Ethylhexanoate, Polyacrylate-13, Polyisobutene, Dimethyl Isosorbide, Benzyl Alcohol, Salicylic Acid, Sorbic Acid, Carnosine, Ilex Paraguariensis Leaf Extract, Maltodextrin, Disodium EDTA, TGF-beta 3 (sh-Polypeptide- 5), IGF-1 (sh-Oligopeptide-2)

Accelerator No. 2 Ingredients:

Water (Aqua), Butylene Glycol, Glycerin, C12-15 Alkyl Benzoate, Capric/Caprylic Triglyceride, Cetearyl Alcohol, Human Bone Marrow Stem Cell Conditioned Media, hBD3 (sh-Oligopeptide- 33), Tetrahexyldecyl Ascorbate, Bakuchiol, Tocopheryl Acetate, Iris Florentina Root Extract, Pentylene Glycol, Tamarindus Indica Seed Gum, Sodium Hyaluronate, Candelilla/Jojoba/Rice Bran Polyglyceryl-3 Esters, Glyceryl Stearate, Sodium Stearoyl Lactylate, Tremella Fuciformis Sporocarp Extract, Betaine, Potassium Sorbate, Glycosphingolipids, Tasmannia Lanceolata Fruit Extract, Syzygium Luehmannii Fruit Extract, Kunzea Pomifera Fruit Extract, Magnesium Aluminum Silicate, Limanthes Alba (Meadowfoam) Seed Oil, Simmondsia Chinensis (Jojoba) Seed Oil, Thioctic Acid, Ubiquinone, Xanthan Gum, Ethyl Linoleate, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol

Regenzyme Mask:

Water (Aqua), Glycerin, Lactobacillus/Pumpkin Fruit Ferment Filtrate, Lactobacillus/Punica Granatum Fruit Ferment Extract, Caprylic/Capric Triglyceride, Stearic Acid, Cetyl Alcohol, Hamamelis Virginiana (Witch Hazel) Water, Bromelain, Papain, Eclipta Prostrata Extract, Citric Acid, Glyceryl Stearate, Xanthan Gum, Titanium Dioxide, Squalane, Ficin, Protease, Astaxanthin, Moringa Oleifera Seed Extract, Melia Azadirachta (Neem) Leaf Extract, Cyamopsis Tetragonoloba (Guar) Gum, Cymbopogon Schoenanthus (Lemongrass) Oil, Citrus Aurantium Dulcis (Orange) Peel Oil, Citrus Grandis (Grapefruit) Peel Oil, Citrus Limon (Lemon) Peel Oil, Santalum Austrocaledonicum (Sandalwood) Wood Oil, Lonicera Japonica (Honeysuckle) Flower Extract, Lonicera Caprifolium (Honeysuckle) Flower Extract, Tocopherol (D-alpha), Glycine Soja (Soybean) Oil, Passiflora Incarnata (Passionflower) Flower Extract, Alcohol, Allyl Caproate, Phytic Acid, Polysorbate 20, Carbomer, Sodium Hydroxide, Fragrance/Parfum

FAQ

The stem cells are sourced only from the bone marrow of young, healthy, pre-screened adult donors. Stem cell cytokines also contain none of the original cell parts themselves, only the beneficial growth factors they produce.

The healing chemical signals produced by the mesenchymal stem cells (growth factors and cytokines) are harvested. The products are 100% free of inflammatory cells, cell fragments, RNA, or DNA.

The Serum contains only the harvested growth factors and cytokines.

The formulation is very stable and does not require refrigeration
The point after opening is recommended at twelve months
The expiration is two years